Nokomis Florida Hotels, Cube Shadow Drawing, Fastest Way To Germinate Strawberry Seeds, Kahlia Chamberlain Foster Care, Pumpkin Portable Dvd Player Reviews, Samsung Slide-in Range Installation Instructions, " /> Nokomis Florida Hotels, Cube Shadow Drawing, Fastest Way To Germinate Strawberry Seeds, Kahlia Chamberlain Foster Care, Pumpkin Portable Dvd Player Reviews, Samsung Slide-in Range Installation Instructions, " />

meropenem side effects in cats

J Antimicrob Chemother 24(suppl a (1989): 311-20, 12. Eur J Clin Microbiol Infect Dis 10 (1991): 85-8, 13. Medically reviewed by Drugs.com. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Papich, MG, Riviere, JE. Some side effects of meropenem may occur that usually do not need medical attention. Clin Infect Dis. Cats are very susceptible to the vestibular effects of amikacin. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Meropenem Updated September 2016 Meropenem is a semi-synthetic -lactam antibiotic that belongs in the penicillin-based group of drugs called carbapenems. Along with its needed effects, meropenem may cause some unwanted effects. NLM Demographic data are included in Table Meropenem. Verscheijden LFM, Koenderink JB, de Wildt SN, Russel FGM. Nausea 6. doi: 10.1093/clinids/24.supplement_2.s266. Development of a physiologically-based pharmacokinetic pediatric brain model for prediction of cerebrospinal fluid drug concentrations and the influence of meningitis. Eur J Drug Metab Pharmacokinet. General Description: Meropenem. Cerner Multum, Inc. "UK Summary of Product Characteristics." has been prescribed for your pet for the treatment of an infection caused by susceptible bacteria because other less expensive antibiotics were not effective or unacceptable because of their adverse effects. Vomiting Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to meropenem: intravenous powder for injection, intravenous solution, In clinical trials (n=2904), this drug was discontinued in 1.2% of patients due to side effects; 5 deaths were possibly drug-related. Wilson SE "Results of a randomized, multicenter trial of meropenem versus clindamycin/tobramycin for the treatment of intra-abdominal infections." Approximately 70% of meropenem is excreted via the kidneys, thus dosage adjustments are required for patients with renal impairment. COVID-19 is an emerging, rapidly evolving situation. Huizinga WK, Warren BL, Baker LW, Valleur P, Pezet DM, Hoogkamp-Korstanjep JA, Karran SJ "Antibiotic monotherapy with meropenem in the surgical management of intra-abdominal infections." Many Enterobacteriaceaethat are resistant to other antimicrobials will be susceptible to meropenem; therefore, use should be strictly reserved for infections caused by organisms that are resistant to other antimicrobial choices. has been prescribed for your pet for the treatment of an infection caused by susceptible bacteria because other less expensive antibiotics were not effective or unacceptable because of their adverse effects. The pharmacology of meropenem, a new carbapenem antibiotic. Those who are allergic to other β-lactam antibiotics are more likely to be allergic to meropenem as well. Three dogs were excluded from the age count because of an unknown birth date. Get the latest public health information from CDC: https://www.coronavirus.gov. Get the latest research from NIH: https://www.nih.gov/coronavirus. These side effects may go away during treatment as your body adjusts to the medicine. Zeneca Pharmaceuticals, Wilmington, DE. Imipenem should not be used in animals with known hypersensitivity or allergy to the drug or other beta-lactams. Plasma and CSF pharmacokinetics of meropenem in neonates and young infants: results from the NeoMero studies. Headache 5. Meropenem. Kimberly A. Toussaint, Jason C. Gallagher, in Side Effects of Drugs Annual, 2014. The safety of imipenem/cilastatin has not been established for animals that are pregnant or lactating. [Ref], Uncommon (0.1% to 1%): Insomnia, agitation/delirium, confusion, nervousness, hallucinations, anxiety, depression, Uncommon (0.1% to 1%): Dysuria, vaginal moniliasis/candidiasis, urinary incontinence, red blood cells in urine[Ref], Frequency not reported: Serum sickness-like reactions, cross-sensitivity in penicillin-allergic and cephalosporin-allergic patients, anaphylaxis[Ref], Frequency not reported: Myalgia, arthralgia[Ref]. Crit Care Med 30 (2002): 2580-3, 20. Rev Infect Dis. 1997 Feb;24 Suppl 2:S266-75. Upset stomach or throwing up. They have occurred most commonly in patients with CNS disorders (e.g., history of seizures, brain lesions) or with bacterial meningitis and/or renal dysfunction. Drugs 67 (2007): 1027-1052, 4. Merrem (meropenem)." Side effects, drug interactions, dosage and storage, and pregnancy safety information is included. Cerner Multum, Inc. "Australian Product Information." Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Its advantage over imipenem is that it is more soluble and can be administered in less fluid volume and more rapidly. US Brand Name. doi: 10.1093/clinids/24.supplement_2.s249. Although not all of these side effects may occur, if they do occur they may need medical attention. [Ref], Common (1% to 10%): Pain, inflammation, sepsis/septicemia, shock, accidental injury, Uncommon (0.1% to 1%): Chest pain, fever, back pain, chills, pelvic pain, peripheral edema, abdominal enlargement[Ref], Common (1% to 10%): Inflammation at the injection site, phlebitis/thrombophlebitis, pain at the injection site, Uncommon (0.1% to 1%): Injection site reactions, edema at the injection site[Ref], Common (1% to 10%): Rash (including diaper/nappy area moniliasis), pruritus, Uncommon (0.1% to 1%): Urticaria, sweating, skin ulcer, Postmarketing reports: Toxic epidermal necrolysis, Stevens-Johnson syndrome, angioedema, erythema multiforme, severe skin reactions[Ref], Common (1% to 10%): Apnea, pharyngitis, pneumonia, Uncommon (0.1% to 1%): Respiratory disorder, dyspnea, pleural effusion, asthma, increased cough, hypoxia, lung edema, Frequency not reported: Respiratory failure[Ref], Heart failure occurred more often in patients with moderately severe renal dysfunction. 2. Meropenem Study Group." Meropenem may also interact with some other medications. Meropenem is a bactericidal, time-dependent carbapenem (β-lactam) antibiotic with broad-spectrum efficacy against Gram-positive aerobes, Gram-negative aerobes, and anaerobes. Meropenem. PLoS Comput Biol. Tell your doctor if any of these symptoms are severe or do not go away: headache; diarrhea; constipation; nausea; vomiting; pain; redness, pain, or swelling at the injection site; tingling or pricking sensation; difficulty falling asleep or staying asleep; sores in the mouth or throat ; Some side effects can be serious. Category: Veterinary. Recommend consultation with a urinary or infectious disease veterinary specialist or veterinary pharmacologist prior to use. Bax RP, Bastain W, Featherstone A, Wilkinson DM, Hutchison M, Haworth SJ "The pharmacokinetics of meropenem in volunteers." Share this conversation. Approximately 70% of meropenem is excreted via the kidneys, thus dosage adjustments are required for patients with renal impairment. Second-Generation Effects Lactation. 1. Wiseman LR, Wagstaff AJ, Brogden RN, Bryson HM. Available for Android and iOS devices. Hamacher J, Vogel F, Lichey J, Kohl FV, Diwok K, Wendel H, Lode H "Treatment of acute bacterial exacerbations of chronic obstructive pulmonary disease in hospitalised patients--a comparison of meropenem and imipenem/cilastatin. Diarrhea 4. Meropenem is a carbapenem antibiotic that appears to be widely distributed in tissues and is eliminated by both excretion and metabolism. Side Effects; Products and services. Embil JM, Soto NE, Melnick DA "A post hoc subgroup analysis of meropenem versus imipenem/cilastatin in a multicenter, double-blind, randomized study of complicated skin and skin-structure infections in patients with diabetes mellitus." Satisfied Customers: 7,210. Read the side effects of Meropenem as described in the medical literature. eCollection 2019. Cependant, certains patients, parents et soignants sont formés pour administrer MEROPENEM MYLAN 1 g, poudre … You may report side effects to Health Canada at 1-866-234-2345. Description and Brand Names. "Product Information. Byrne S, Maddison J, Connor P, Doughty I, Dodd M, Jenney M, Webb AK, David TJ "Clinical evaluation of meropenem versus ceftazidime for the treatment of Pseudomonas spp. Meropenem is a carbapenem antibiotic that appears to be widely distributed in tissues and is eliminated by both excretion and metabolism. Drugs 68 (2008): 803-38, 5. Veterinarian: Dr. Susan, Veterinarian replied 9 years ago. infections in cystic fibrosis patients." What are some other side effects of Meropenem? Epub 2016 Aug 27. doi: 10.1371/journal.pcbi.1007117. Ralph ED, John M, Rieder MJ, Bombassaro AM "Serum Sickness-like Reaction Possibly Associated with Meropenem Use." In case of any doubt consult your doctor or pharmacist. References. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Headache. Clin Infect Dis 36 (2003): E149-E151. O 0, 3. Adverse Side Effects. Carbapenem resistance is a growing problem in human medicine and is expecte… [Ref], Common (1% to 10%): Nausea, diarrhea, vomiting, constipation, gastrointestinal disorder, abdominal pain, Uncommon (0.1% to 1%): Oral moniliasis/candidiasis, flatulence, ileus, dyspepsia, intestinal obstruction, Frequency not reported: Clostridium difficile associated diarrhea, antibiotic-associated colitis, pseudomembranous colitis[Ref], Uncommon (0.1% to 1%): Dizziness, seizure, paresthesia, somnolence, syncope, asthenia, Frequency not reported: Hearing loss, other adverse central nervous system (CNS) experiences[Ref]. Meropenem resists the actions of many enzymes that degrade most other penicillins and penicillin-like anti-infectives. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Therapeutic Effects: Bactericidal action against susceptible bacteria. eCollection 2019 Jun. If you notice any behavioral or physiological side effects when administering this medication, contact your veterinarian immediately. The pharmacokinetic parameters for meropenem are similar to those for imipenem/cilastatin, with the exception of meropenem's smaller volume of distribution. It inhibits bacterial cell wall synthesis by binding to several penicillin-binding proteins (PBPs) in gram-negative and gram-positive bacteria resulting in cell wall assembly arrest and eventually bacterial cell lysis. Nilsson-Ehle I, Hutchison M, Haworth SJ, Norrby SR "Pharmacokinetics of meropenem compared to imipenem-cilastatin in young, healthy males." Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. 2019 Jun;44(3):433-436. doi: 10.1007/s13318-018-0524-4. Storage of the Drug. is supplied in 20 mL and 30 mL injection vials containing sufficient meropenem to deliver 500 mg or 1 g, respectively. Serious side effects include Clostridium difficile infection, seizures, and allergic reactions including anaphylaxis. Seizures and other adverse CNS experiences have been reported. Liu TJ, Lam JP "Piperacillin-tazobactam-induced acute interstitial nephritis with possible meropenem cross-sensitivity in a patient with osteomyelitis." Meropenem (Merrem) use in cats, is it safe? Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. One of the adverse effects caused from imipenem therapy is seizures. You may need medical attention if you get some of the side effects. Description: Meropenem is a β-lactam antibiotic. Hemsell DL, Martens MG, Faro S, Gall S, Mcgregor JA "A multicenter study comparing intravenous meropenem with clindamycin plus gentamicin for the treatment of acute gynecologic and obstetric pelvic infections in hospitalized women." Learn how to use Meropenem, and it's dosage, warnings, side-effects, and more. Kempf P, Bauernfeind A, Muller A, Blum J "Meropenem monotherapy versus cefotaxime plus metronidazole combination treatment for serious intra-abdominal infections." It is the same drug class as Imipenem. Meropenem injection is used to treat infections caused by bacteria. 5 mg/kg PO q24h (cats)10–20 mg/kg q24h (dogs) ... Meropenem: 8.5 mg/kg SC/IV q 12 (SC) or 8 (IV)h: Reserve for treatment of multidrug-resistant infections, particularly those caused by Enterobacteriaceae or Pseudomonas aeruginosa. Animal ages ranged from 0 to 19 years of age, with a median of 11 years.  |  Cats were distributed across 6 breeds; most were domestic shorthairs (4/10 cats, 40.0%). Clipboard, Search History, and several other advanced features are temporarily unavailable. amoxicillin, Keflex, doxycycline, triamcinolone, metronidazole, azithromycin, ciprofloxacin, clindamycin, Augmentin, Flagyl. 2016 Sep;5(9):475-83. doi: 10.1002/psp4.12101. Plasma and Renal Cortex Meropenem Concentrations in Patients Undergoing Percutaneous Renal Biopsy. Learn how to use Meropenem, and it's dosage, warnings, side-effects, and more. The median age of dogs was 10 years (range, 1‐14), and the median age of cats was 13 years (range, 0‐19). From: Side Effects of Drugs Annual, 2011. J01DH02 - meropenem ; Belongs to the class of carbapenems. Clinical Application of Pharmacokinetics: Basis for Rational Dose Selection in a Critically Ill Patient on Renal Replacement Therapy. Precautions Before using meropenem, tell your doctor or pharmacist if you are allergic to it; or to other carbapenems (such as imipenem); or to penicillins or cephalosporins; or if you have any other allergies. Seizures occurred more often in patients with moderately severe renal dysfunction. Bluish lips or skin 2. chills 3. cold, clammy skin 4. confusion 5. dizziness 6. fainting 7. fast heartbeat 8. fast, weak pulse 9. fever 10. itching, skin rash 11. lightheadedness 12. rapid, shallow breathing 13. sweating All drugs may cause side effects. Therefore, inform your veterinarian of any and all medications your pet may be taking. These side effects may go away during treatment as your body adjusts to the medicine. In the United States, amikacin is not FDA-approved for use in cattle or other food animals. Zhanel GG, Wiebe R, Dilay L, et al. Cats Label dose: 10-15mg/kg PO or IV q12h: For serious anaerobic infections: 25 – 50 mg/kg PO or IV q12h: For enteritis caused by Clostridium difficile: 62.5mg/cat PO q12h for 5d: For metronidazole benzoate: 25 mg/kg PO q12h : Dogs Label dose: 10-15mg/kg PO q12h: Brand Name(s) Flagyl® Background. 2016. We comply with the HONcode standard for trustworthy health information -, unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness, vomiting of blood or material that looks like coffee grounds, white patches in the mouth, tongue, or throat, blistering, peeling, or loosening of the skin, holding false beliefs that cannot be changed by fact, large, hive-like swelling on the face, eyelids, tongue, throat, hands, legs, feet, or genitals, red skin lesions, often with a purple center, seeing, hearing, or feeling things that are not there, sores, ulcers, or white spots in the mouth or on the lips, unusual excitement, nervousness, or restlessness, redness and swelling at the injection site, redness, swelling, or soreness of the tongue, excess air or gas in the stomach or bowels. Antimicrob Agents Chemother 42 (1998): 1233-8, 8. NIH 1. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Some side effects may not be reported. Therefore, unlike imipenem, meropenem can be used without dehydropeptidase inhibitors to obtain a consistently high concentration in the urine without nephrotoxic effects. Meropenem. Clin Infect Dis 24 ( Suppl (1997): s222-30, 9. 1. Clin Infect Dis 24 Suppl 2 (1997): s197-206, 7. Find patient medical information for Meropenem Intravenous on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Zhou W, Johnson TN, Xu H, Cheung S, Bui KH, Li J, Al-Huniti N, Zhou D. CPT Pharmacometrics Syst Pharmacol. Mouton YJ, Beuscart C "Empirical monotherapy with meropenem in serious bacterial infections. J Antimicrob Chemother 36(suppl a (1995): 121-33, 18. Nilsson-Ehle I, Hutchison M, Haworth SJ, Norrby SR. Eur J Clin Microbiol Infect Dis. You may report them to the FDA. doi: 10.1093/clinids/7.supplement_3.s447. This medicine helps most people with infections, but it may have unwanted side effects in a few people. Amikacin can be stored at room temperature and is stable for up to 2 years. Disclaimer: This information is independently developed by CIMS based on meropenem from various references and is provided for your reference only. Ask Your Own Veterinary Question. The dose was 2000 mg every 8 h for all patients, except for those with adverse drug effects or renal impairment (creatinine clearance [CrCL] ≤50 ml/minute), for whom the dose was reduced to 1000 mg every 8 h at the discretion of the attending … All medicines can have side effects. Normalement, c'est un médecin ou une infirmière qui vous administrera MEROPENEM MYLAN 1 g, poudre pour solution injectable/pour perfusion. Infection 24 (1996): 473-9, 11. Last updated on Jul 26, 2020. O 0, 14. Meropenem reduces plasma valproate concentrations, affording two mechanisms for an increased risk of seizures in patients with epilepsy, epileptogenic effect of meropenem, and loss of antiepileptic action of valproate [46A,47A,48A,49A,50A,51A,52c]. The urinary recovery of meropenem is as high as that of imipenem in combination with cilastatin, an inhibitor of renal dehydropeptidase. Am J Health Syst Pharm 69 (2012): 1109, 19. General Description: Meropenem. However, clinical trials are necessary to confirm clinical efficacy of the proposed dosage regimen. No information is available on the effects of meropenem on the breast-fed child or on milk production. The pharmacokinetic parameter … Like all -lactam antibiotics, meropenem interferes with bacterial wall synthesis after binding to penicillin-binding proteins (PBPs) in the cell wall. Drugs. Clin Pharmacokinet. Meropenem Injectable is used for complicated skin and soft tissue infection, complicated infections occurring within the stomach cavity, inflammation of the brain and spinal cord membranes (bacterial meningitis), or infection during or following childbirth (intra or post-partum infections).  |  [Ref], Common (1% to 10%): Anemia, hypochromic anemia, bleeding events (including gastrointestinal hemorrhage, melena, epistaxis, hemoperitoneum), thrombocythemia, Uncommon (0.1% to 1%): Increased platelets, increased eosinophils, decreased platelets, decreased hemoglobin, decreased hematocrit, decreased white blood cells, decreased prothrombin time, decreased partial thromboplastin time, leukocytosis, eosinophilia, thrombocytopenia, leukopenia, neutropenia, Postmarketing reports: Agranulocytosis, positive Coombs test (direct or indirect), hemolytic anemia[Ref], Shock occurred more often in patients with moderately severe renal dysfunction. Germovsek E, Lutsar I, Kipper K, Karlsson MO, Planche T, Chazallon C, Meyer L, Trafojer UMT, Metsvaht T, Fournier I, Sharland M, Heath P, Standing JF; NeoMero Consortium. J Antimicrob Chemother. 1985 Jul-Aug;7 Suppl 3:S447-51. CPT Pharmacometrics Syst Pharmacol.  |  Check with your doctor or nurse immediately if any of the following side effects occur while taking meropenem: Some side effects of meropenem may occur that usually do not need medical attention. 2019 Jun 13;15(6):e1007117. Free E-newsletter Subscribe to Housecall. Spectrum: Active against the following gram-positive organisms: Staphylococcus aureus, Streptococcus pneumoniae, Viridans group streptococci, Enterococcus faecalis. 2019 Nov 19;2019:1368397. doi: 10.1155/2019/1368397. In repeat dose studies of up to 6 months duration only minor effects were seen including a decrease in red cell parameters in dogs. Baldwin CM, Lyseng-Williamson KA, Keam SJ "Meropenem : a review of its use in the treatment of serious bacterial infections." However, many people have no side effects or only have minor side effects. is supplied in 20 mL and 30 mL injection vials containing sufficient meropenem to deliver 500 mg or 1 g, respectively. A review of its antibacterial activity, pharmacokinetic properties and clinical efficacy. Common side effects include nausea, diarrhea, constipation, headache, rash, and pain at the site of injection. [Ref], Common (1% to 10%): Peripheral vascular disorder, Uncommon (0.1% to 1%): Heart failure, heart arrest, tachycardia, hypertension, myocardial infarction, pulmonary embolus, bradycardia, hypotension[Ref], Common (1% to 10%): Increased transaminases, Uncommon (0.1% to 1%): Increased AST, increased ALT, increased bilirubin, hepatic failure, cholestatic jaundice/jaundice[Ref], Common (1% to 10%): Hypoglycemia, increased alkaline phosphatase, increased lactate dehydrogenase, Uncommon (0.1% to 1%): Anorexia, hypervolemia, hypokalemia[Ref], Uncommon (0.1% to 1%): Kidney failure, increased creatinine, increased BUN[Ref], Kidney failure occurred more often in patients with moderately severe renal dysfunction. Learn about the prescription drug meropenem (Merrem) used to treat a variety of bacterial infections. Meropenem, when administered to cats at a dose of 10 mg/kg q12h,, is effective against bacteria with MIC values of 6 μg/ml, 7 μg/ml and 10 μg/ml for IV, IM and SC administration, respectively. Please enable it to take advantage of the complete set of features! Sign up now. Answered in 15 minutes by: 12/5/2010. Side effects of Merrem include nausea, vomiting, diarrhea, constipation, headache, or soreness, redness, or swelling at the injection site. Shah PM, Heller A, Fuhr HG, Walther F, Halir S, Schaumann R, Bohme A, Jung B, Kohler A, Lipsschulte C, Stille W "Empirical monotherapy with meropenem versus imipenem/cilastatin for febrile episodes in neutropenic patients." Meropenem - Indications, Dosage, Side Effects and Precautions General Brands Prescription Contraindications Side effects Dosage How to Take Warning Storage Video Medindia Pharmacokinetics: Absorption: Time to peak plasma concentration: Approx 1 hour (tissues); 2-3 hours (CSF). J Antimicrob Chemother 36(suppl a (1995): 179-89, 16. Drug information provided by: IBM Micromedex. Adequate and well-controlled studies of this drug in pregnant women are lacking, and this drug should be used during pregnancy only if clearly needed. Meropenem (Meropenem Hikma®; Hikma Pharma, Gräfelfing, Germany) was administered as a prolonged infusion over 4 h using a syringe pump. Anemia If experienced, these tend to have a Less Severe expression 1. Meropenem is generally well tolerated by the central nervous system. This site needs JavaScript to work properly. Meropenem has been reported to be excreted in human milk. Tell your doctor as soon as possible if you do not feel well while you are receiving meropenem. Clin Ther 28 (2006): 1164-74, 6. J Antimicrob Chemother 36(suppl a (1995): 135-43, 17. If experienced, these tend to have a Severe expression 1. Meropenem injection may cause side effects. The IV LD50 of meropenem in rodents is greater than 2000 mg/kg. This drug is ototoxic and nephrotoxic. In a review of 4872 patients, diarrhea, rash, nausea/vomiting, injection site inflammation, thrombocytosis and increased hepatic enzymes were reported most often. Meropenem, one of the newest of the carbapenem class of drugs has antibacterial activity approximately equal to, or greater than imipenem. Infection 24 (1996): 480-4, 10. Side effects not requiring immediate medical attention. Diarrhea. "Comparative Review of the Carbapenems." COPD Study Group." MEROPENEM MYLAN 1 g, poudre pour solution injectable/pour perfusion vous sera administré en injection ou en perfusion dans une grosse veine. Predictive Performance of Physiologically Based Pharmacokinetic and Population Pharmacokinetic Modeling of Renally Cleared Drugs in Children. Merrem IV; Descriptions. Constipation 3. The concentration of meropenem in breast milk was evaluated in a study of a 41-year-old woman treated for a postpartum urinary tract infection caused by extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli with meropenem 1 g IV q 8 h. Pharmacokinetics of meropenem compared to imipenem-cilastatin in young, healthy males.

Nokomis Florida Hotels, Cube Shadow Drawing, Fastest Way To Germinate Strawberry Seeds, Kahlia Chamberlain Foster Care, Pumpkin Portable Dvd Player Reviews, Samsung Slide-in Range Installation Instructions,

Close